3-(10,10-Dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-1-propanamine Hydrochloride

Name	melitracen hydrochloride
Synonyms	MELITRACEN HYDROCHLORLD MELITRACEN HYDROCHLORID melitracen hydrochloride Melitracen Hydrochlorlde Melitracen hydrochloride 3-(10,10-dimethylanthracen-9(10H)-ylidene)-N,N-dimethylpropan-1-amine 3-[10,10-dimethyl-9(10H)-anthrylidene]-N,N-dimethylpropylamine hydrochloride 3-[10,10-Dimethyl-9(10H)-anthrylidene]-N,N-dimethylpropylamine hydrochloride 9-(3-Dimethylaminopropylidene)-10,10-dimethyl-9,10-dihydroanthracene Hydrochloride 3-(10,10-Dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-1-propanamine Hydrochloride 1-Propanamine, 3-(10,10-dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-, hydrochloride
CAS	10563-70-9
EINECS	234-150-5
InChI	InChI=1/C21H25N/c1-21(2)19-13-7-5-10-17(19)16(12-9-15-22(3)4)18-11-6-8-14-20(18)21/h5-8,10-14H,9,15H2,1-4H3

Molecular Formula	C21H26ClN
Molar Mass	327.89084
Density	1.046g/cm³
Melting Point	245-248°C
Boling Point	399.1°C at 760 mmHg
Flash Point	174.4°C
Vapor Presure	1.4E-06mmHg at 25°C
Appearance	Crystalline solid
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.607
Use	Content determination
In vivo study	Single oral administration of either Imipramine or Melitracen produces a marked and long lasting mydriasis in mice. The mydriatic effect of Melitracen is more marked and longer lasting. Melitracen is more effective with respect to behavioral excitement. Single oral administration of Melitracen produces lowering of the catechol amine levels in the brain stem, the cerebral cortex, the spleen, and the adrenals. No significant changes in catecholamine levels of the brain stem, the cerebral cortex, and the spleen were observed in rats receiving daily doses of Melitracen for 13 and 15 weeks. The adrenalin level in the adrenals, however, is slightly decreased.

Toxicity

LD50 i.v. in mice: 52 mg/kg (Petersen)

biological activity	Melitracen hydrochloride (Thymeol) is a potential dopamine D1/2 receptor antagonist with antidepressant effects.
target	5-HT receptor

Last Update：2024-04-09 02:00:05

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3-(10,10-Dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-1-propanamine Hydrochloride Request for Quotation